Article
Apolipoprotein ε7 allele in memory complaints: insights through protein structure prediction.
Clinical interventions in aging - 1 Jan 2017
Youn Young Chul, Lim Yong Kwan, Han Su-Hyun, Giau Vo Van, Lee Mi-Kyung, Park Kwang-Yeol, Kim SangYun, Bagyinszky Eva, An Seong Soo A, Kim Hye Ryoun
Abstract excerpt
PURPOSE: APOE ε7 gene is a rare mutant form of APOE ε3. The mutation occurs in the lipid-binding domain of APOE. Based on the protein's structure, APOE ε7 is expected to function in lipid and β-amyloid metabolism, similar to APOE ε4. However, unlike that for APOE ε4, the mechanisms responsible for Alzheimer's disease (AD) cases associated with APOE ε7 expression have not been elucidated. The present study aims to...
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