Article
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 1999
Clave E, Molldrem J, Hensel N, Raptis A, Barrett A J
Abstract excerpt
The curative effect of allogeneic bone marrow transplantation (BMT) is in part due to an alloresponse of donor lymphocytes against recipient leukemia termed the graft versus leukemia (GvL) effect. To identify target antigens for the GvL response on leukemia cells, we looked for polymorphism of pr...
Topics
- Alleles
- Bone Marrow Transplantation
- Exons
- Female
- Flow Cytometry
- Gene Frequency
- Genotype
- Graft vs Tumor Effect
- HLA-A Antigens
- Histocompatibility Testing
- Humans
- Leukemia, Myeloid
- Male
- Myeloblastin
- Peptide Fragments
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Protein Binding