Article
Interferon-gamma inhibits the myofibroblastic phenotype of rat palatal fibroblasts induced by transforming growth factor-beta1 in vitro.
FEBS letters - 8 Jan 1999
Yokozeki M, Baba Y, Shimokawa H, Moriyama K, Kuroda T
Abstract excerpt
Interferon-gamma (IFN-gamma), a multifunctional cytokine, has been noted as a potential therapeutic agent for various fibrotic disorders, including excessive scar tissue formation. We previously reported that transforming growth factor-beta1 (TGF-beta1) induced the myofibroblastic phenotype in pa...
Topics
- Actins
- Animals
- Cells, Cultured
- Cicatrix
- Collagenases
- Fibroblasts
- Gene Expression
- Interferon-gamma
- Matrix Metalloproteinase 1
- Muscle, Smooth
- Palate
- Phenotype
- Procollagen
- RNA, Messenger
- Rats
- Recombinant Proteins
- Swine
- Transforming Growth Factor beta