Article
Characterization of the bleomycin resistance determinant encoded on the transposon Tn5.
FEBS letters - 8 Jan 1999
Kumagai T, Nakano T, Maruyama M, Mochizuki H, Sugiyama M
Abstract excerpt
The transposon Tn5 carries a gene, ble, which confers resistance to bleomycin (Bm) and gives a survival advantage to its host cell. We found that the ble gene product, designated BLMT, is a binding protein with a strong affinity for Bm. BLMT quenched both the antibacterial and DNA-cleaving activities of Bm, when incubated with the antibiotic. An electron spin resonance spin-trapping analysis showed that BLMT...
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