Article
Bleomycin-resistance gene derived from the transposon Tn5 confers selective advantage to Escherichia coli K-12.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991
Blot M, Meyer J, Arber W
Abstract excerpt
The plasmid pRAB2 contains a silent operon derived from the transposon Tn5 and carrying the gene neo for neomycin-kanamycin resistance and a truncated ble gene (ble333) for bleomycin resistance. Spontaneous mutants that express the two resistances provide Escherichia coli cells an improved fitness during the phase of decline in the absence of the antibiotics. It is shown that the ble333 gene product is...
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