Article
Z and S mutations of the alpha1-antitrypsin gene and the risk of chronic obstructive pulmonary disease.
American journal of respiratory cell and molecular biology - 1 Feb 1999
Sandford A J, Weir T D, Spinelli J J, Paré P D
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) has been associated with heterozygosity for the Z and S alleles of the alpha1-antitrypsin gene in some studies, but these observations have not been confirmed by others. Cigarette smoking is the major risk factor for COPD and may have been a confoundin...
Topics
- Aged
- Alleles
- Base Sequence
- DNA Primers
- Female
- Heterozygote
- Humans
- Lung Diseases, Obstructive
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Respiratory Function Tests
- Risk Factors
- alpha 1-Antitrypsin