Article
alpha1-antitrypsin genotypes and the acute-phase response to open heart surgery.
American journal of respiratory and critical care medicine - 1 May 1999
Sandford A J, Chagani T, Spinelli J J, Paré P D
Abstract excerpt
A mutation in the 3' region of the alpha1-antitrypsin (alpha1-AT) gene is associated with chronic obstructive pulmonary disease (COPD). However, the reason for this association is unknown. The mutation does not cause alpha1-AT deficiency but in vitro studies suggest it could attenuate the rise in alpha1-AT levels during the acute-phase response. Therefore, we sought an association between the 3' mutation and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.