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Article

Variable phenotypes associated with aromatase (CYP19) insufficiency in humans.

The Journal of clinical endocrinology and metabolism - 1 Mar 2007

Lin Lin, Ercan Oya, Raza Jamal, Burren Christine P, Creighton Sarah M, Auchus Richard J, Dattani Mehul T, Achermann John C

Abstract excerpt

CONTEXT: The P450 enzyme aromatase (CYP19) plays a crucial role in the endocrine and paracrine biosynthesis of estrogens from androgens in many diverse estrogen-responsive tissues. Complete aromatase deficiency has been reported in a small number of 46,XX girls with genital ambiguity and absent pubertal development, but it is unknown whether nonclassic phenotypes exist. OBJECTIVE: The objective of this study was...

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Identifiers

PMID: 17164303
DOI: 10.1210/jc.2006-1181
PMCID: PMC1955738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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