Site-directed mutagenesis of the human D antigen: definition of D epitopes on the sixth external domain of the D protein expressed on K562 cells.

doi:10.1046/j.1537-2995.1999.39199116890.x

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Article

Site-directed mutagenesis of the human D antigen: definition of D epitopes on the sixth external domain of the D protein expressed on K562 cells.

Transfusion - 1 Jan 1999

Liu W, Smythe J S, Scott M L, Jones J W, Voak D, Avent N D

Abstract excerpt

BACKGROUND: The antigens of the human Rh system are of great clinical significance in transfusion medicine and pregnancy. Of the Rh system antigens, D is clinically the most important, being one of the most immunogenic structures arising from human cells. The human D antigen represents a collecti...

Topics

Antibodies, Monoclonal
Epitope Mapping
Epitopes
Humans
K562 Cells
Mutagenesis, Site-Directed
Phenotype
Protein Structure, Tertiary
RNA, Messenger
Rh-Hr Blood-Group System

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