Article
Isolation, characterization, and family study of DTI, a novel partial D phenotype affecting the fourth external loop of D polypeptides.
Transfusion - 1 Apr 2002
Omi Toshinori, Takahashi Junko, Seno Taiko, Tanaka Mitsunobu, Hirayama Fumiya, Matsuo Michie, Ueda Naoki, Obara Kenryo, Okuda Hiroshi, Iwamoto Sadahiko, Tani Yoshihiko, Kajii Eiji
Abstract excerpt
BACKGROUND: The Rh system is the most polymorphic of the blood group systems and is of major importance in transfusion medicine. The partial D phenotypes lack one or more of the D epitopes. These variants appear to have arisen through hybrid RhD-CE-D or by spontaneous point mutations in RhD. The serologic findings and the molecular characterization of a novel partial D phenotype, termed DTI, are presented here....
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