Article
A mutant of deleted variant of hepatocyte growth factor (dHGF) with alanine substitution in the N-terminal basic region has higher activity in vivo.
Biochemical and biophysical research communications - 19 Jan 1999
Kinosaki M, Yamaguchi K, Yamashita Y, Uematsu Y, Aihara H, Masunaga H, Morinaga T, Higashio K
Abstract excerpt
In a previous study, we generated a mutant of dHGF (deleted variant of hepatocyte growth factor), termed #2, with higher specific activity than dHGF in assays of mitogenic activity on rat hepatocytes and America opossum kidney epithelial cells (OK). In the present study, we examine in vivo hepato...
Topics
- Acute Kidney Injury
- Alanine
- Amino Acid Substitution
- Animals
- Blood Proteins
- CHO Cells
- Cell Division
- Cell Line
- Cholesterol
- Cholesterol, HDL
- Cricetinae
- Epithelial Cells
- Genetic Variation
- Hepatocyte Growth Factor
- Kidney
- Liver
- Male
- Mercuric Chloride