Article
Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure.
Transplantation - 27 May 2005
Chen Yong, Kobayashi Naoya, Suzuki Satoshi, Soto-Gutierrez Alejandro, Rivas-Carrillo Jorge David, Tanaka Kimiaki, Navarro-Alvarez Nalú, Fukazawa Takuya, Narushima Michiki, Miki Atsushi, Okitsu Teru, Amemiya Hiroshi, Tanaka Noriaki
Abstract excerpt
BACKGROUND: Considering the scarcity of donor livers, it is extremely important to establish a functional culture method for isolated hepatocytes. As a tool for maintaining hepatocyte functions in vitro, dHGF, a variant of HGF (hepatocyte growth factor) with a deletion of five amino acids, attracted our attention because it is less cytotoxic compared with HGF. METHODS: We evaluated growth, albumin production,...
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