Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

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Article

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1999

Jean-Claude B J, Mustafa A, Watson A J, Damian Z, Vasilescu D, Chan T H, Leyland-Jones B

Abstract excerpt

Human brain and colon tumor cell lines SF-188 (Mer+) and WiDR (Mer+), which express the DNA repair protein O6-methylguanine-DNA methyl transferase (MGMT), were 3- to 30-fold less sensitive to temozolomide, mitozolomide, and N, N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) than the MGMT-deficient tum...

Topics

Antineoplastic Agents, Alkylating
Benzazepines
Brain Neoplasms
Cell Cycle
Colonic Neoplasms
Enzyme Inhibitors
Flow Cytometry
Glioma
Humans
O(6)-Methylguanine-DNA Methyltransferase
Phenotype
Pyridines
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9918549

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9918549-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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