Article
Pneumolysin in pneumococcal adherence and colonization.
Microbial pathogenesis - 1 Dec 1998
Rubins J B, Paddock A H, Charboneau D, Berry A M, Paton J C, Janoff E N
Abstract excerpt
The universal and highly conserved production of pneumolysin, the major pneumococcal cytolysin, among clinical isolates of Streptococcus pneumoniae and the previously reported association of pneumolysin production with increased pneumococcal adherence to respiratory epithelium in organ cultures suggest that this toxin might be important for nasopharyngeal colonization. We confirmed that pneumolysin-deficient...
Topics
- Animals
- Bacterial Adhesion
- Bacterial Proteins
- Cell Line
- Epithelial Cells
- Female
- Humans
- Mice
- Mice, Knockout
- Mutation
- Nose
- Pharynx
- Specific Pathogen-Free Organisms
- Streptococcus pneumoniae
- Streptolysins