Article
icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells.
Infection and immunity - 1 Jan 2002
Molmeret Maelle, Alli O A Terry, Zink Steven, Flieger Antje, Cianciotto Nicholas P, Kwaik Yousef Abu
Abstract excerpt
The final step of the intracellular life cycle of Legionella pneumophila and other intracellular pathogens is their egress from the host cell after termination of intracellular replication. We have previously isolated five spontaneous mutants of L. pneumophila that replicate intracellularly similar to the wild-type strain but are defective in pore formation-mediated cytolysis and egress from mammalian and...
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