Mutation analysis of CYP2D6 locus in the Korean population: identification of rare poor metabolizer alleles at the nucleotide level.

Article

Mutation analysis of CYP2D6 locus in the Korean population: identification of rare poor metabolizer alleles at the nucleotide level.

Molecules and cells - 31 Dec 1998

Ryu S W, Kim Y J, Kim E

Abstract excerpt

The CYP2D6 loci of one hundred and eight genetically unrelated Koreans were analyzed. The G1934A mutation which causes aberrant splicing, thereby producing nonfunctional enzymes and is responsible for 70% of poor metabolizer (PM) phenotype among Caucasians, was found in three heterozygous individ...

Topics

Alleles
Cytochrome P-450 CYP2D6
DNA
DNA Mutational Analysis
DNA Primers
Humans
Korea
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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