Article
A role for RNA helicase A in post-transcriptional regulation of HIV type 1.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Li J, Tang H, Mullen T M, Westberg C, Reddy T R, Rose D W, Wong-Staal F
Abstract excerpt
Retroviruses must bypass the tight coupling of splicing and nuclear export of mRNA in their replication cycle because unspliced genomic RNA and incompletely spliced mRNA must be exported to the cytoplasm for packaging or translation. This process is mediated by a cis-acting constitutive transport element (CTE) for simple retroviruses and by the trans-acting viral protein Rev in concert with its response element...
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