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Article

Estimates of the genomic mutation rate for detrimental alleles in Drosophila melanogaster.

Genetics - 1 Jun 2004

Charlesworth Brian, Borthwick Helen, Bartolomé Carolina, Pignatelli Patricia

Abstract excerpt

The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male backcrosses of heterozygotes for a wild-type third chromosome. Egg-to-adult viability was assayed...

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Identifiers

PMID: 15238530
DOI: 10.1534/genetics.103.025262
PMCID: PMC1470907

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Source receipt: pubmed, retrieved 7 Sept 2026.

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