Article
Somatostatin receptor-3 mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal.
Biochimica et biophysica acta - 1 Mar 2011
War Sajad A, Somvanshi Rishi K, Kumar Ujendra
Abstract excerpt
In the present study, we describe the role of cytoplasmic terminal (C-tail) domain in regulating coupling to adenylyl cyclase, signaling, and apoptosis in human embryonic kidney (HEK-293) cells transfected with wild type (wt)-hSSTR3 and C-tail deleted mutants. Cells transfected with wt-hSSTR3 and C-tail mutants show comparable membrane expression; however, display decreased expression in presence of agonist....
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