Article
Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases.
The EMBO journal - 15 Jan 1999
Müller A, Günther D, Düx F, Naumann M, Meyer T F, Rudel T
Abstract excerpt
The porin (PorB) of Neisseria gonorrhoeae is an intriguing bacterial factor owing to its ability to translocate from the outer bacterial membrane into host cell membranes where it modulates the infection process. Here we report on the induction of programmed cell death after prolonged infection o...
Topics
- Adenosine Triphosphate
- Amino Acid Chloromethyl Ketones
- Apoptosis
- Bacterial Outer Membrane Proteins
- Calcium
- Calpain
- Cell Line
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Enzyme Activation
- HeLa Cells
- Humans
- Ion Transport
- Mutation
- Neisseria gonorrhoeae
- Porins