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Article

Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases.

The EMBO journal - 15 Jan 1999

Müller A, Günther D, Düx F, Naumann M, Meyer T F, Rudel T

Abstract excerpt

The porin (PorB) of Neisseria gonorrhoeae is an intriguing bacterial factor owing to its ability to translocate from the outer bacterial membrane into host cell membranes where it modulates the infection process. Here we report on the induction of programmed cell death after prolonged infection of epithelial cells with pathogenic Neisseria species. The underlying mechanism we propose includes translocation of the...

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Identifiers

PMID: 9889191
DOI: 10.1093/emboj/18.2.339
PMCID: PMC1171129

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