Article
The use of computational chemistry in the study of sex steroid biosynthesis.
Endocrine research - 1 Jan 2000
Auchus R J
Abstract excerpt
Many of the steroidogenic enzymes and cofactor proteins are bound to intracellular membranes, frustrating standard methods of structure determination. Structural models of steroidogenic P450 enzymes, however, may be predicted from the x-ray crystal structures of prokaryotic P450s. Using P450-BMP...
Topics
- Gonadal Steroid Hormones
- Humans
- Models, Chemical
- Mutation
- Steroid 17-alpha-Hydroxylase