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Article

Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans.

Journal of human hypertension - 1 Feb 2004

Jalil J E, Ocaranza M P, Oliveri C, Córdova S, Godoy I, Chamorro G, Braun S, Fardella C, Michel J-B, Lavandero S

Abstract excerpt

Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(1-7)]. In humans, the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism determined plasma ACE levels by 40%. In rats, a similar polymorphism determines ACE levels which are inversely associated to NEP activity. The objective of this study is to evaluate the relationship between...

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PMID: 14730327
DOI: 10.1038/sj.jhh.1001646

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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