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Article

Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

15 Dec 2000

Abstract excerpt

The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated...

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PMID: 11118147
DOI: 10.1126/science.290.5499.2140

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