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Article

Two-Helper RNA System for Production of Recombinant Semliki Forest Virus Particles

1 Feb 1999

Abstract excerpt

Alphavirus expression systems based on suicidal virus particles carrying recombinant replicons have proven to be a very efficient way to deliver genes for heterologous protein expression. However, present strategies for production of such particles have biosafety limitations due to the generation, by RNA recombination, of replication-proficient viruses (RPVs). Here we describe a new packaging system for Semliki...

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PMID: 9882310
DOI: 10.1128/jvi.73.2.1092-1098.1999

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