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Article

Stable alphavirus packaging cell lines for Sindbis virus- and Semliki Forest virus-derived vectors

13 Apr 1999

Abstract excerpt

Alphavirus vectors are being developed for possible human vaccine and gene therapy applications. We have sought to advance this field by devising DNA-based vectors and approaches for the production of recombinant vector particles. In this work, we generated a panel of alphavirus vector packaging cell lines (PCLs). These cell lines were stably transformed with expression cassettes that constitutively produced RNA...

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PMID: 10200308
DOI: 10.1073/pnas.96.8.4598

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