Article
The position of the ZEBRA activation domain does not influence its biological activity.
Virus research - 1 Oct 1998
Asković S, Taylor W, Baumann R
Abstract excerpt
Epstein-Barr virus (EBV) is a human herpesvirus which latently infects B lymphocytes. EBV encodes a unique transcriptional activator, known as ZEBRA, which can disrupt viral latency in B cells and induce lytic viral replication. Furthermore, ZEBRA has been shown to bind at the EBV origin of lytic replication, and is necessary for viral DNA replication to occur. Previously we demonstrated that heterologous...
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