The position of the ZEBRA activation domain does not influence its biological activity.

doi:10.1016/s0168-1702(98)00089-6

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Article

The position of the ZEBRA activation domain does not influence its biological activity.

Virus research - 1 Oct 1998

Asković S, Taylor W, Baumann R

Abstract excerpt

Epstein-Barr virus (EBV) is a human herpesvirus which latently infects B lymphocytes. EBV encodes a unique transcriptional activator, known as ZEBRA, which can disrupt viral latency in B cells and induce lytic viral replication. Furthermore, ZEBRA has been shown to bind at the EBV origin of lytic...

Topics

B-Lymphocytes
Cell Line
DNA Replication
DNA-Binding Proteins
Genes, Reporter
Herpesvirus 4, Human
Humans
Mutation
Recombinant Fusion Proteins
Trans-Activators
Transcriptional Activation
Viral Proteins
Virus Activation
Virus Replication

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