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Article

Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.

The Journal of biological chemistry - 1 Jan 1999

Richardson A, van der Vies S M, Keppel F, Taher A, Landry S J, Georgopoulos C

Abstract excerpt

Previous work has shown that the GroEL-GroES interaction is primarily mediated by the GroES mobile loop. In bacteriophage T4 infection, GroES is substituted by the gene 31-encoded cochaperonin, Gp31. Using a genetic selection scheme, we have identified a new set of mutations in gene 31 that affect interaction with GroEL; all mutations result in changes in the mobile loop of Gp31. Biochemical analyses reveal that...

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Identifiers

PMID: 9867810
DOI: 10.1074/jbc.274.1.52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.PMID 9867810Read ↗

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Creating the Functional Single-Ring GroEL-GroES Chaperonin Systems via Modulating GroEL-GroES Interaction.Semantic proximity Read ↗

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