Article
Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.
The Journal of biological chemistry - 1 Jan 1999
Richardson A, van der Vies S M, Keppel F, Taher A, Landry S J, Georgopoulos C
Abstract excerpt
Previous work has shown that the GroEL-GroES interaction is primarily mediated by the GroES mobile loop. In bacteriophage T4 infection, GroES is substituted by the gene 31-encoded cochaperonin, Gp31. Using a genetic selection scheme, we have identified a new set of mutations in gene 31 that affec...
Topics
- Alleles
- Amino Acid Sequence
- Bacteriophage T4
- Chaperonin 60
- Chaperonins
- Citrate (si)-Synthase
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Protein Folding
- Spectrometry, Fluorescence
- Viral Proteins