Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli.

Abstract excerpt

N-Acetylglucosamine (GlcNAc) and N-acetylneuraminic acid (NANA) are good carbon sources for Escherichia coli K-12, whereas N-acetylmannosamine (ManNAc) is metabolized very slowly. The isolation of regulatory mutations which enhanced utilization of ManNAc allowed us to elucidate the pathway of its...

Topics

• Acetylglucosamine
• Aldose-Ketose Isomerases
• Bacterial Proteins
• Biological Transport, Active
• Chromosome Mapping
• Escherichia coli
• Escherichia coli Proteins
• Genes, Bacterial
• Hexosamines
• Membrane Proteins
• Membrane Transport Proteins
• Mutation
• N-Acetylneuraminic Acid
• Operon
• Phosphoenolpyruvate Sugar Phosphotransferase System
• Phosphorylation