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The NAG Sensor NagC Regulates LEE Gene Expression and Contributes to Gut Colonization by Escherichia coli O157:H7.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Le Bihan Guillaume, Sicard Jean-Félix, Garneau Philippe, Bernalier-Donadille Annick, Gobert Alain P, Garrivier Annie, Martin Christine, Hay Anthony G, Beaudry Francis, Harel Josée, Jubelin Grégory

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 are human pathogens responsible for bloody diarrhea and renal failures. EHEC employ a type 3 secretion system to attach directly to the human colonic epithelium. This structure is encoded by the locus of enterocyte effacement (LEE) whose expression is regulated in response to specific nutrients. In this study, we show that the mucin-derived sugars...

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Identifiers

PMID: 28484684
DOI: 10.3389/fcimb.2017.00134
PMCID: PMC5401889

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