Article
Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region.
Tissue antigens - 1 Nov 1998
Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz E I, Kovalchuk L, Sochnev A, Adojaan B, Podar T, Knip M, Simell O, Koskenvuo M, Akerblom H K, Ilonen J
Abstract excerpt
The high incidence of insulin-dependent diabetes mellitus (IDDM) in Finland contrasts strikingly with the low rates in the neighbouring populations of countries in the Eastern Baltic region: Estonia, Latvia and Russia. To evaluate the possible contribution of genetic factors to these differences, the frequencies of HLA-DQB1 alleles and relevant DQB1-DQA1 or DQB1-DRB1 haplotypes associated with IDDM risk or...
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