Article
The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization.
Molecular and cellular biology - 1 Jan 1999
Rudolph C, Kunz C, Parisi S, Lehmann E, Hartsuiker E, Fartmann B, Kramer W, Kohli J, Fleck O
Abstract excerpt
We have identified in the fission yeast Schizosaccharomyces pombe a MutS homolog that shows highest homology to the Msh2 subgroup. msh2 disruption gives rise to increased mitotic mutation rates and increased levels of postmeiotic segregation of genetic markers. In bandshift assays performed with...
Topics
- Alleles
- Base Pair Mismatch
- Base Sequence
- Chromosomes, Fungal
- Cloning, Molecular
- DNA Repair
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Genes, Mating Type, Fungal
- Meiosis
- Mitosis
- Molecular Sequence Data