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Article

The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization.

Molecular and cellular biology - 1 Jan 1999

Rudolph C, Kunz C, Parisi S, Lehmann E, Hartsuiker E, Fartmann B, Kramer W, Kohli J, Fleck O

Abstract excerpt

We have identified in the fission yeast Schizosaccharomyces pombe a MutS homolog that shows highest homology to the Msh2 subgroup. msh2 disruption gives rise to increased mitotic mutation rates and increased levels of postmeiotic segregation of genetic markers. In bandshift assays performed with msh2Delta cell extracts, a general mismatch-binding activity is absent. By complementation assays, we showed that S....

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Identifiers

PMID: 9858548
DOI: 10.1128/MCB.19.1.241
PMCID: PMC83882

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