Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor.

The EMBO journal - 15 Dec 1998

Yan C, Lee L H, Davis L I

Abstract excerpt

The yeast AP-1-like transcription factor, Yap1p, activates genes required for the response to oxidative stress. Yap1p is normally cytoplasmic and inactive, but will activate by nuclear translocation if cells are placed in an oxidative environment. Here we show that Yap1p is a target of the beta-karyopherin-like nuclear exporter, Crm1p. Yap1p is constitutively nuclear in a crm1 mutant, and Crm1p binds to a nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Carrier Proteins
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Nuclear Proteins

Share to Protein Binding

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9857197
DOI: 10.1093/emboj/17.24.7416
PMCID: PMC1171086

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor.PMID 9857197Read ↗

Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress.Semantic proximity Read ↗

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.Semantic proximity Read ↗

Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.Semantic proximity Read ↗

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.Semantic proximity Read ↗

Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast.Semantic proximity Read ↗

Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis.Semantic proximity Read ↗

Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies.Semantic proximity Read ↗

Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast.Semantic proximity Read ↗

Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance.Semantic proximity Read ↗

Importin/karyopherin protein family members required for mRNA export from the nucleus.Semantic proximity Read ↗

A novel conserved nuclear localization signal is recognized by a group of yeast importins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.