Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of Human Granzyme B Expression by Glucocorticoids

1 Dec 1998

Abstract excerpt

The serine protease granzyme B is an essential component of the granule exocytosis pathway, a major apoptotic mechanism used by cytotoxic T lymphocytes and natural killer cells to induce target cell apoptosis. Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to PARP inhibition in cancer therapy
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9857074
DOI: 10.1074/jbc.273.52.35326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of Human Granzyme B Expression by GlucocorticoidsPMID 9857074Read ↗

Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A.Semantic proximity Read ↗

Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.Semantic proximity Read ↗

Glucocorticoid receptors in human airwaysSemantic proximity Read ↗

Anti-inflammatory Actions of Glucocorticoids: Molecular MechanismsSemantic proximity Read ↗

Competition between glucocorticoid receptor and NFκB for control of the human FasL promoterSemantic proximity Read ↗

Glucocorticoid receptor beta splice variant expression in patients with high and low activity of systemic lupus erythematosus.Semantic proximity Read ↗

Controversies in granzyme biologySemantic proximity Read ↗

Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis.Semantic proximity Read ↗

Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.Semantic proximity Read ↗

Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.Semantic proximity Read ↗

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.Semantic proximity Read ↗

Regulation of S100A10 by the PML-RAR-α oncoprotein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.