Article
p53 and protein kinase C independent induction of growth arrest and apoptosis by bryostatin 1 in a highly metastatic mammary epithelial cell line: In vitro versus in vivo activity.
International journal of molecular medicine - 1 Jun 1998
Wang H, Mohammad R M, Werdell J, Shekhar P V
Abstract excerpt
We have evaluated the effects of bryostatin 1 on growth of a highly malignant p53-null mouse mammary tumor line, 4T1, and the mechanism by which bryostatin 1 inhibits in vitro growth and in vivo development of tumor and metastases from the orthotopic site. Bryostatin 1 at 20-400 nM concentrations...
Topics
- Animals
- Antineoplastic Agents
- Apoptosis
- Blotting, Western
- Bryostatins
- Cell Division
- DNA, Recombinant
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Vectors
- Isoenzymes
- Lactones