(E)-2'-deoxy-2'-(fluoromethylene) cytidine potentiates radioresponse of two human solid tumor xenografts.

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Article

(E)-2'-deoxy-2'-(fluoromethylene) cytidine potentiates radioresponse of two human solid tumor xenografts.

Cancer research - 1 Dec 1998

Sun L Q, Li Y X, Guillou L, Coucke P A

Abstract excerpt

Antitumor and radiosensitizing effects of (E)-2'-deoxy-2'-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide reductase, were evaluated on nude mice bearing s.c. human C33-A cervix cancer and U-87 MG glioblastoma xenografts. FMdC given once daily has a dose-dependent antitumor...

Topics

Animals
Antineoplastic Agents
Cell Cycle
Combined Modality Therapy
Deoxycytidine
Female
Glioblastoma
Humans
Mice
Mice, Nude
Mutation
Neoplasm Transplantation
Radiation-Sensitizing Agents
Transplantation, Heterologous
Tumor Suppressor Protein p53
Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 9850073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9850073-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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