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Article

Comparison of antineoplastic activity of 2',2'-difluorodeoxycytidine and cytosine arabinoside against human myeloid and lymphoid leukemic cells.

Anti-cancer drugs - 1 Feb 1991

Bouffard D Y, Momparler L F, Momparler R L

Abstract excerpt

2',2'-difluorodeoxycytidine (known as dFdC, Gemcitabine and LY188011) is a new analog of deoxycytidine which has demonstrated excellent antineoplastic activity against many kinds of solid tumors and leukemic cell lines. We were interested in the comparison of the antineoplastic activity of this new antimetabolite with cytosine arabinoside (ARA-C) against HL-60 myeloid, RPMI-8392 B-lymphoid and Molt-3 T-lymphoid...

Topics

Antimetabolites, Antineoplastic
Cell Division
Cytarabine
DNA, Neoplasm
Deoxycytidine
Humans
Kinetics
Leukemia, Experimental
Leukemia, Lymphoid
Leukemia, Myeloid
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Gemcitabine

Source

Identifiers

PMID: 1958852
DOI: 10.1097/00001813-199102000-00007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1958852-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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