Article
Molecular characterisation of a panel of human ovarian carcinoma xenografts.
European journal of cancer (Oxford, England : 1990) - 1 Aug 1998
Codegoni A M, Nicoletti M I, Buraggi G, Valoti G, Giavazzi R, D'Incalci M, Landoni F, Maneo A, Broggini M
Abstract excerpt
In a panel of 16 human ovarian tumours transplanted in nude mice, the expression of genes involved in cell cycle regulation and in response to drug treatment were characterised. In the 16 tumours analysed we could not detect overexpression of Erb-B2 oncogene while expression of MDR1 mRNA was not detected in 11/15 samples and was low in 4/15 tumours. Only three tumours had mutations in the p53 gene exons 5-8 and...
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