Article
p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2006
Henriksson Eva, Baldetorp Bo, Borg Ake, Kjellen Elisabeth, Akervall Jan, Wennerberg Johan, Wahlberg Peter
Abstract excerpt
To investigate the response of tumour growth to cisplatin treatment, in relation to p53 mutation and cyclin D1 dysregulation on DNA and protein level, biopsies from seven xenografted human squamous cell carcinomas from the head and neck were analysed with immunohistochemistry for p53 expression a...
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