Article
Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
Legro R S, Driscoll D, Strauss J F, Fox J, Dunaif A
Abstract excerpt
Our preliminary family studies have suggested that some female first-degree relatives of women with polycystic ovary syndrome (PCOS) have hyperandrogenemia per se. It was our hypothesis that this may be a genetic trait and thus could represent a phenotype suitable for linkage analysis. To investigate this hypothesis, we examined 115 sisters of 80 probands with PCOS from unrelated families. PCOS was diagnosed by...
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