Article
Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism - 1 May 2002
Legro Richard S, Kunselman Allen R, Demers Lawrence, Wang Steve C, Bentley-Lewis Rhonda, Dunaif Andrea
Abstract excerpt
There is an inherited susceptibility to polycystic ovary syndrome (PCOS). Some investigators have suggested that premature male-pattern balding is a male phenotype in PCOS families, but this remains controversial. We recently reported evidence for an autosomal monogenic abnormality in ovarian and adrenal steroidogenesis in the sisters of women with PCOS. We performed this study to determine whether we could...
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