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Article

Effect of ovariectomy in heart failure-prone SHHF/Mcc-facp rats.

The American journal of physiology - 1 Dec 1998

Sharkey L C, Holycross B J, Park S, McCune S A, Hoversland R, Radin M J

Abstract excerpt

The importance of the loss of ovarian function to the progression of hypertension and heart disease in women is controversial. We investigated whether ovariectomy would accelerate development of hypertension, congestive heart failure, and neurohumoral activation in adult spontaneous hypertension heart failure (SHHF) rats, a genetic model of heart failure. Six months after ovariectomy, no significant differences...

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Identifiers

PMID: 9843886
DOI: 10.1152/ajpregu.1998.275.6.R1968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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