Article
Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea.
The American journal of physiology - 1 Dec 1998
Yang H, Jiang W, Furth E E, Wen X, Katz J P, Sellon R K, Silberg D G, Antalis T M, Schweinfest C W, Wu G D
Abstract excerpt
The pathogenesis of diarrhea in intestinal inflammatory states is a multifactorial process involving the effects of inflammatory mediators on epithelial transport function. The effect of colonic inflammation on the gene expression of DRA (downregulated in adenoma), a chloride-sulfate anion transporter that is mutated in patients with congenital chloridorrhea, was examined in vivo as well as in an intestinal...
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