Article
Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea.
The American journal of physiology - 1 Dec 1998
Yang H, Jiang W, Furth E E, Wen X, Katz J P, Sellon R K, Silberg D G, Antalis T M, Schweinfest C W, Wu G D
Abstract excerpt
The pathogenesis of diarrhea in intestinal inflammatory states is a multifactorial process involving the effects of inflammatory mediators on epithelial transport function. The effect of colonic inflammation on the gene expression of DRA (downregulated in adenoma), a chloride-sulfate anion transp...
Topics
- Animals
- Animals, Genetically Modified
- Antiporters
- Caco-2 Cells
- Carrier Proteins
- Chloride-Bicarbonate Antiporters
- Chlorides
- Colitis
- Colitis, Ulcerative
- Diarrhea
- Female
- Gene Expression Regulation
- HLA-B27 Antigen
- Humans
- Immunohistochemistry