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Article

Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

1 May 1993

Abstract excerpt

A cDNA, which we call DRA (for down-regulated in adenoma) has been isolated. Its mRNA is expressed exclusively in normal colon tissue, probably only in the mucosal epithelia. Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. The DRA gene appears to be a single-copy gene present on chromosome 7, a chromosome associated with colorectal tumorigenesis. The...

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Identifiers

PMID: 7683425
DOI: 10.1073/pnas.90.9.4166

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