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Article

Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea.

The American journal of physiology - 1 Jan 1999

Moseley R H, Höglund P, Wu G D, Silberg D G, Haila S, de la Chapelle A, Holmberg C, Kere J

Abstract excerpt

Congenital chloride diarrhea (CLD) is a recessively inherited disorder characterized by massive loss of chloride in stool. We previously identified mutations in the downregulated in adenoma (DRA) gene in patients with CLD and demonstrated that DRA encodes an intestine-specific sulfate transporter. To determine whether DRA is an intestinal chloride transporter and how mutations affect transport, Xenopus oocytes...

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Identifiers

PMID: 9886994
DOI: 10.1152/ajpgi.1999.276.1.G185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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