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Article

Estradiol reverses TGF-β1-stimulated type IV collagen gene transcription in murine mesangial cells

1 Jun 1998

Abstract excerpt

We have previously shown that estradiol suppresses types I and IV collagen synthesis by mesangial cells grown in the presence of serum. In the present study, we examined the interaction between estradiol and transforming growth factor-beta (TGF-beta) on collagen IV synthesis. In a luciferase reporter gene construct containing the type IV collagen promoter and 1-chain regulatory sequences, we found that TGF-beta1...

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Identifiers

PMID: 9841504
DOI: 10.1152/ajprenal.1998.274.6.f1113

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