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Article

In Situ Analysis of Interleukin-1-Induced Transcription of cox-2 and il-8 in Cultured Human Myometrial Cells

2 Dec 2003

Abstract excerpt

The specific binding of transcription factors to DNA has been shown to be inhibited by chromatin structure and increased by cooperative interactions with other proteins. Consequently, in situ analysis using chromatin immunoprecipitation offers the most accurate view of transcriptional control. Transient transfection studies and in vitro analyses of IL-1-induced cox-2 transcription in a number of cell types have...

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PMID: 14645117
DOI: 10.1210/en.2003-1310

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