Article
Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica.
DNA and cell biology - 1 Nov 1998
Sherburn T E, Gale J M, Ley R D
Abstract excerpt
The tumor suppressor gene, CDKN2A (p16), encodes a cyclin-dependent kinase inhibitor and functions as a negative regulator in the retinoblastoma pathway that blocks cell cycle progression from the G1 phase. The gene has been found to be deleted, truncated, mutated, or silenced by promoter methyla...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Complementary
- Humans
- Melanoma
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms, Radiation-Induced
- Opossums
- Phylogeny
- Proteins
- Rats
- Sequence Alignment
- Tumor Cells, Cultured