Article
Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines.
Oncogene - 17 Aug 1995
Pollock P M, Yu F, Qiu L, Parsons P G, Hayward N K
Abstract excerpt
The CDKN2 gene, encoding the cyclin dependent kinase inhibitor p16, is a tumour suppressor gene involved in melanoma and maps to chromosome band 9p22. Mutations or interstitial deletions of this gene have been found both in the germline of familial melanoma cases and somatically in melanoma cell lines. Previous mutation analyses of melanoma cell lines have indicated a high frequency of C:G to T:A transitions,...
Topics
- Base Sequence
- Carrier Proteins
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Primers
- Exons
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Melanoma
- Molecular Sequence Data