Expression of<i>CYP2E1</i>in Human Lung and Kidney during Development and in Full‐Term Placenta: A Differential Methylation of the Gene is Involved in the Regulation Process

Abstract excerpt

Methylation of dinucleotide CG residues located in the 5' end of the CYP2E1 gene has been demonstrated to play a role in the control of gene expression in the human developing liver. This study was undertaken to examine the CYP2E1 RNA content of human lung, kidney and full-term placenta and to determine whether the expression of CYP2E1 was controlled by its methylation status in these tissues. CYP2E1 was...

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