Article
A genetic study of signaling processes for repression of PHO5 transcription in Saccharomyces cerevisiae.
Genetics - 1 Dec 1998
Lau W W, Schneider K R, O'Shea E K
Abstract excerpt
In the yeast Saccharomyces cerevisiae, transcription of a secreted acid phosphatase, PHO5, is repressed in response to high concentrations of extracellular inorganic phosphate. To investigate the signal transduction pathway leading to transcriptional regulation of PHO5, we carried out a genetic selection for mutants that express PHO5 constitutively. We then screened for mutants whose phenotypes are also dependent...
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